Trifluoroacetic acid → HCID 14213080, compound

HRID 362467Notes

Reaction equation

HRID 362467 reaction equation
FC(F)(F)C(O)=O.[C:8]1([CH2:14][CH:15]([CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])[C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[C:27]([CH2:26][CH:15]([CH2:14][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:16]([O:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:17])([OH:29])=[O:28]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 14213077(R)-1-Benzyl 4-tert-butyl 2-benzylsuccinate

Product 1

HCID 14213080HCID 14213080, compoundYield 62.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

8 ml of trifluoroacetic acid are added, at 0° C., to a solution of 2 g (5.6 mmol) of phenylmethyl 1,1-dimethylethyl 2-(phenylmethyl)-1,4-butanedioate in 16 ml of dichloromethane. After 7 h at room temperature, the mixture is evaporated to dryness and the residue is recrystallized from cyclohexane. 1.05 g of a white product are obtained.

Workup

  1. customthe mixture is evaporated to dryness
  2. customthe residue is recrystallized from cyclohexane

Sources & evidence

ORD record
ord-1e42076ff9874623ba395359a355d072
Source dataset
uspto-grants-1999_02
Patent number
US05869518

Reaction notes

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