Hydrochloric Acid → HCID 131721120, compound

HRID 362700Notes

Reaction equation

HRID 362700 reaction equation
[CH3:1][N:2]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=1)[C:3](=[O:24])[C@@H:4]1[C@@H:8]([CH2:9][CH3:10])[CH2:7][CH2:6][N:5]1C(C(OC(C)(C)C)=O)[C@@H]1CCCN1.Cl>CCOC(C)=O>[CH3:1][N:2]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=1)[C:3](=[O:24])[C@@H:4]1[C@@H:8]([CH2:9][CH3:10])[CH2:7][CH2:6][NH:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131721119HCID 131721119, compound

Product 1

HCID 131721120HCID 131721120, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

N-[(t-Butyloxycarbonyl)-pyrrolidin-2(S)-ylmethyl]-3(S)-ethyl-proline-N-methyl-N-(3-chlorophenylmethyl) amide (0.150 g, 0.32 mmol) was dissolved in EtOAc (15 mL), cooled to -20° C. and saturated with HCl gas. The solution was stirred at 0° C. for 1 h, then at 25° C. for 1 hour, then concentrated to dryness to give pyrrolidin-2(S)-ylmethyl]-3(S)-ethyl-proline-N-methyl-N-(3-chlorophenylmethyl) amide which was used without further purification.

Workup

  1. waitat 25° C. for 1 hour
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-cb945000f1e14b67b174209d8c444486
Source dataset
uspto-grants-1999_02
Patent number
US05869682

Reaction notes

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