Potassium Carbonate → 4-Benzyl-6-(3,4-dichlorophenyl)-6-[2-[4-(2-dimethylaminothiazol-4-yl)-4-phenylpiperid-1-yl]ethyl]morpholin-3-one dihydrochloride

HRID 362733Notes

Reaction equation

HRID 362733 reaction equation
[CH2:1]([N:8]1[CH2:13][C:12]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=2)([CH2:14][CH2:15]OS(C)(=O)=O)[O:11][CH2:10][C:9]1=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH3:41][N:42]([CH3:60])[C:43]1[S:44][CH:45]=[C:46]([C:48]2([C:54]3[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=3)[CH2:53][CH2:52][NH:51][CH2:50][CH2:49]2)[N:47]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:27].[ClH:27].[CH2:1]([N:8]1[CH2:13][C:12]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=2)([CH2:14][CH2:15][N:51]2[CH2:50][CH2:49][C:48]([C:46]3[N:47]=[C:43]([N:42]([CH3:60])[CH3:41])[S:44][CH:45]=3)([C:54]3[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH2:53][CH2:52]2)[O:11][CH2:10][C:9]1=[O:29])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 195913894-Benzyl-6-(3,4-dichlorophenyl)-6-[2-(methanesulfonyloxy)ethyl]morpholin-3-oneHCID 212005544-[2-(Dimethylamino)thiazol-4-yl]-4-phenylpiperidine p-toluenesulfonate

Product 1

HCID 212005984-Benzyl-6-(3,4-dichlorophenyl)-6-[2-[4-(2-dimethylaminothiazol-4-yl)-4-phenylpiperid-1-yl]ethyl]morpholin-3-one dihydrochlorideYield 131.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound is prepared by the procedure described in EXAMPLE 41 from 1.1 g of the compound obtained in step B of EXAMPLE 14, 1.3 g of 4-[2-(dimethylamino)thiazol-4-yl]-4-phenylpiperidine p-toluenesulfonate, 0.97 g of K2CO3 and 4 ml of DMF to give 0.76 g of the expected product. M.p.=155°-160° C.

Workup

  1. customThis compound is prepared by the procedure

Sources & evidence

ORD record
ord-cc860e5e0b174ba28201ca241b2bc623
Source dataset
uspto-grants-1999_02
Patent number
US05869663

Reaction notes

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