Hydrochloric Acid → HCID 54561485, compound

HRID 362787Notes

Reaction equation

HRID 362787 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[ClH:16]>O>[NH2:12][C:9]1[CH:10]=[CH:11][C:6]([C:4](=[O:5])[CH2:1][CH2:2][CH2:3][Cl:16])=[CH:7][C:8]=1[N+:13]([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3015566(4-Amino-3-nitrophenyl) cyclopropyl ketone

Product 1

HCID 54561485HCID 54561485, compoundYield 84.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of cyclopropyl (4-amino-3-nitrophenyl)methanone (80 g), prepared as described in U.S. Pat. No. 3,657,267, and concentrated HCl (420 ml) was stirred and refluxed for 30 minutes. The reaction mixture was cooled and water was added. The precipitate was filtered off, washed with water and dried, yielding 80 g (84.5%) of 1-(4-amino-3-nitrophenyl)-4-chloro-1-butanone; mp. 150° C. (intermediate 10).

Workup

  1. customprepared
  2. temperaturerefluxed for 30 minutes
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe precipitate was filtered off
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-691bf9ae43ad4bc9aab6867bb23de34c
Source dataset
uspto-grants-1999_02
Patent number
US05872131

Reaction notes

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