反应详情

3-Acetyl-1H-indole (4.00 g, 0.025 mol) was dissolved in dry THF (100 ml), and treated with 80% sodium hydride (0.794 g, 0.0263 mol) with stirring under Ar. After 0.5 h, methyl iodide (2.36 ml, 0.038 mol) was added. After 20 h, the reaction mixture was evaporated under reduced pressure and the residue partitioned between ethyl acetate and water. The organic layer was then dried (Na2SO4), and evaporated under reduced pressure to give the title compound as a pale brown oil which crystallised on standing (4.20 g, 97%).

1. waitAfter 20 h
2. customthe reaction mixture was evaporated under reduced pressure
3. customthe residue partitioned between ethyl acetate and water
4. dry with materialThe organic layer was then dried (Na2SO4)
5. customevaporated under reduced pressure