Acetic Anhydride → 1-acetoxy-2-[2-(N,N-dimethylamino)ethoxy]-1-(1-naphthyl)ethane

HRID 362985Notes

Reaction equation

HRID 362985 reaction equation
Cl.[CH3:2][N:3]([CH2:5][CH2:6][O:7][CH2:8][CH:9]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1)[OH:10])[CH3:4].[C:21](OC(=O)C)(=[O:23])[CH3:22].C(N(CC)CC)C>N1C=CC=CC=1>[C:21]([O:10][CH:9]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1)[CH2:8][O:7][CH2:6][CH2:5][N:3]([CH3:2])[CH3:4])(=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 675980182-[2-(N,N-dimethylamino)ethoxy]-1-(1-naphthyl)ethanol hydrochloride

Product 1

HCID 540332121-acetoxy-2-[2-(N,N-dimethylamino)ethoxy]-1-(1-naphthyl)ethane

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-[2-(N,N-dimethylamino)ethoxy]-1-(1-naphthyl)ethanol hydrochloride was reacted with acetic anhydride in pyridine in the presence of triethylamine to obtain oily 1-acetoxy-2-[2-(N,N-dimethylamino)ethoxy]-1-(1-naphthyl)ethane (compound No. 300).

Sources & evidence

ORD record
ord-b932ab0ea8544f42b11f4e87335e8a9e
Source dataset
uspto-grants-1999_02
Patent number
US05872117

Reaction notes

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