反应详情

温度

80 °C

A mixture of 2.27 g of 4-benzoyloxy-2,6-dichlorophenol, 1.29 g of 2-chlorobenzyl chloride, 1.21 g of potassium carbonate and 50 ml of N,N-dimethylformamide was stirred at 80° C. for 6 hours. The reaction mixture was cooled to room temperature, poured in ice water, and extracted twice with 50 ml of diethyl ether. The combined ether layer was washed with water, and dried with anhydrous magnesium sulfate, followed by removal of the solvent by distillation under reduced pressure. The residue was subjected to silica gel chromatography, which afforded 2.87 g of 1-benzoyloxy-4-(2-chlorobenzyloxy)-3,5-dichlorobenzene (88% yield).

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionextracted twice with 50 ml of diethyl ether
3. washThe combined ether layer was washed with water
4. dry with materialdried with anhydrous magnesium sulfate
5. customfollowed by removal of the solvent by distillation under reduced pressure