反应详情

Glycine was dissolved in a 2:1 mixture by volume of IPA and water. Triethylamine and 1-bromododecane were added to the solution successively and the mixture was kept stirring for more than 7 days. After the solvent was removed, THF was added to the remaining material. Triethylamine hydrobromide was removed by filtration and the filtrate was concentrated. N-n-dodecylglycine was obtained from the concentrated solution by separation and purification by column chromatography with the yield of 26.3%.

1. customAfter the solvent was removed
2. additionTHF was added to the remaining material
3. customTriethylamine hydrobromide was removed by filtration
4. concentrationthe filtrate was concentrated