反应详情

温度

-20 °C

HCl gas was bubbled into a solution of N-(t-Butoxycarbonyl methionine isopropyl ester (20.5 g, 0.07 mol) in EtOAc (200 mL) with stirring and cooling to -20° C. for 10 min. The flask was stoppered and stirred at -20° C. for 1 h, argon was bubbled into the solution to remove excess HCl, then the solution was concentrated to dryness to give a white solid which was used without further purification.

1. stirringstirred at -20° C. for 1 h
2. customargon was bubbled into the solution
3. customto remove excess HCl
4. concentrationthe solution was concentrated to dryness
5. customto give a white solid which
6. customwas used without further purification