反应详情

The 3-(1,2,3,4,5,8-hexahydroindolizin-7-yl)-5-fluoro-1H-indole hydrochloride salt (450 mg, 1.54 mmol) was dissolved in trifluoroacetic acid (7.5 ml) forming an orange solution. The triethylsilane (197 mg, 1.7 mmol) was added and the reaction became colorless. TLC after 5 minutes showed no starting material present. The reaction was concentrated and the resulting oil poured into water and extracted with methylene chloride. The extract was washed with base, dried over sodium sulfate, and concentrated to give the product as a colorless oil.

1. customforming an orange solution
2. concentrationThe reaction was concentrated
3. additionthe resulting oil poured into water
4. extractionextracted with methylene chloride
5. washThe extract was washed with base
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated