Methylamine → HCID 178458307, compound

HRID 363371Notes

Reaction equation

HRID 363371 reaction equation
[OH:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])[N:5]=[C:4]([C:18]([O:20]CC)=O)[CH:3]=1.[CH3:23][NH2:24]>C(O)C>[CH3:23][NH:24][C:18]([C:4]1[CH:3]=[C:2]([OH:1])[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])[N:5]=1)=[O:20]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178458308HCID 178458308, compound

Product 1

HCID 178458307HCID 178458307, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 6-hydroxy-2-(2-propoxyphenyl)pyrimidine-4-carboxylate (0.40 g) and methylamine in industrial methylated spirit (33%, 15 ml) in ethanol (15 ml) was stirred at ambient temperature for 6 hours and then allowed to stand for 3 days. The reaction mixture was evaporated under reduced pressure to yield a crude product which was recrystallized from ethanol to yield the title compound, 0.26 g, m.p. 165°-6° C.

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customto yield a crude product which
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-a5ca7d020d314f52858037bb82026668
Source dataset
uspto-grants-1999_02
Patent number
US05874440

Reaction notes

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