反应详情

温度

60 °C

To a stirred solution of 1,2-dihydro-imidazo[1,5-a]indol-3-one (3 g; 0.0174 moles) in 50 ml of anhydrous dimethylformamide kept under nitrogen atmosphere, 50% NaH (0.84 g; 0.0174 moles) is added. The solution is stirred for 1 hour at 60° C.; then, at room temperature, 4-chloromethyl-5-methyl-1-triphenylmethyl-1H-imidazole (6.5 g; 0.0174 moles) is added. The reaction mixture is stirred for 6 hours at 70° C., then cooled, poured into water and extracted with methylene chloride.

1. stirringThe reaction mixture is stirred for 6 hours at 70° C.
2. temperaturecooled
3. extractionextracted with methylene chloride