反应详情

A mixture of 6hydroxy-7-methoxy-1-tetralone (J. Org. Chem., 1985, 50, 4937) (1.5 g, 7.8 mmol), K2CO3 (1.7 g, 12.3 mmol), and acetone (30 ml) was stirred at reflux under nitrogen for 45 minutes. The reaction was cooled to ambient temperature and a solution of 1-bromo-3-chloropropane (1.9 g, 12.1 mmol) dissolved in 8 ml acetone was dripped into the mixture. After total addition, the reaction was heated to reflux and stirred under nitrogen for 21 hours. The reaction was cooled to ambient temperature land filtered. The filter cake was washed well with acetone and the filtrate was concentrated to yield 2.0 g 6-(3chloropropoxy)-7-methoxy-1-tetralone as an amber oil.

1. temperatureat reflux under nitrogen for 45 minutes
2. additionAfter total addition
3. temperaturethe reaction was heated
4. temperatureto reflux
5. stirringstirred under nitrogen for 21 hours
6. temperatureThe reaction was cooled to ambient temperature land
7. filtrationfiltered
8. washThe filter cake was washed well with acetone
9. concentrationthe filtrate was concentrated