Triethylamine → HCID 86753746, compound

HRID 363724Notes

Reaction equation

HRID 363724 reaction equation
[S:1]1[CH:9]2[C:4]([CH2:5][NH:6][CH2:7][CH2:8]2)=[CH:3][C:2]1=[O:10].[CH3:11][C:12]1[CH:13]=[CH:14][C:15]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:16][CH:17]=1.[CH:22]([Si:25]([CH:30]([CH3:32])[CH3:31])([CH:27]([CH3:29])[CH3:28])Cl)([CH3:24])[CH3:23].C(N(CC)CC)C>C(Cl)Cl>[CH:22]([Si:25]([CH:30]([CH3:32])[CH3:31])([CH:27]([CH3:29])[CH3:28])[O:10][C:2]1[S:1][C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=1)([CH3:24])[CH3:23].[CH3:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 139400Triisopropylsilyl chlorideHCID 451083204-Methylbenzene-1-sulfonic acid--5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one (1/1)

Product 1

HCID 86753746HCID 86753746, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 2.00 g of 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one-p-toluenesulfonate, 1.29 g of triisopropylchlorosilane, 0.66 g of triethylamine and 7 ml of methylene chloride was stirred at room temperature for 3 hours. The produced 2-triisopropylsilyloxy-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-p-toluenesulfonate was not isolated, 0.96 g of 2-chlorobenzyl chloride and 1.21 g of triethylamine were added thereto, and the mixture was allowed to react under further stirring at 40° C. for 10 hours.

Sources & evidence

ORD record
ord-2f61b34043f044bf9823af7967420472
Source dataset
uspto-grants-1999_02
Patent number
US05874581

Reaction notes

Loading…