反应详情

温度

60 °C

To a solution of 10.96 g (50 mmole) of 5-oxo-1-(phenylmethyl)-3-pyrrolidinecarboxylic acid in 150 ml of acetonitrile was added 9.73 g (60 mmole) of carbonyldiimidazole. The reaction was heated to 60° C. for one hour, cooled to room temperature and treated with 4.13 g (70 mmole) of n-propylamine. After stirring for two hours, the solvent was removed in vacuo and the residue partitioned between ether and water. The organic layer was washed with water, 1N hydrochloric acid, dried over magnesium sulfate, filtered, and evaporated invacuo to give 12.0 g of 5-oxo-1-(phenylmethyl)-N-propyl-3-pyrrolidinecarboxamide, mp 86°-87° C.

1. temperaturecooled to room temperature
2. customthe solvent was removed in vacuo
3. customthe residue partitioned between ether and water
4. washThe organic layer was washed with water, 1N hydrochloric acid
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customevaporated invacuo