Hydrochloric Acid → N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-N-(3-phenylthiopropyl)-methylamine

HRID 364077Notes

Reaction equation

HRID 364077 reaction equation
[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[CH:18][C:6]2[CH2:7][C:8](=[O:17])[N:9]([CH2:12][CH2:13][CH2:14][NH:15][CH3:16])[CH2:10][CH2:11][C:5]=2[CH:4]=1.[C:22]1([S:28][CH2:29][CH2:30][CH2:31]Cl)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.Cl>>[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[CH:18][C:6]2[CH2:7][C:8](=[O:17])[N:9]([CH2:12][CH2:13][CH2:14][N:15]([CH3:16])[CH2:31][CH2:30][CH2:29][S:28][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 2696063-Chloropropyl phenyl sulfideHCID 100172197,8-Dimethoxy-3-[3-(methylamino)propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Product 1

HCID 13579669N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-N-(3-phenylthiopropyl)-methylamine

Procedure

The title compound is prepared from N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-methylamine and 3-phenylthiopropylchloride analogously to Example 3. M.p. of the hydrochloride: 130°-140° C.

Workup

  1. custom130°-140° C.

Sources & evidence

ORD record
ord-bf50155e211a4258ba84f758630ecc97
Source dataset
uspto-grants-1986_08
Patent number
US04604389

Reaction notes

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