Piperidine → 1,3-Di-cyclohexylmethyl-8-piperidinyl Xanthine

HRID 3641Notes

Reaction equation

HRID 3641 reaction equation
[CH:1]1([CH2:7][N:8]2[C:17](=[O:18])[C:16]3[NH:15][C:14](Br)=[N:13][C:12]=3[N:11]([CH2:20][CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[C:9]2=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:1]1([CH2:7][N:8]2[C:17](=[O:18])[C:16]3[NH:15][C:14]([N:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)=[N:13][C:12]=3[N:11]([CH2:20][CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[C:9]2=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 102025051,3-Di-cyclohexylmethyl-8-bromo xanthine

Product 1

HCID 101133491,3-Di-cyclohexylmethyl-8-piperidinyl Xanthine

Procedure

The title compound was prepared from 1,3-di-cyclohexylmethyl-8-bromo xanthine (0.7 g, 0.0017 mol) and piperidine (0.28 g, 0,003 mol) using an analogous procedure to that described in Example 19. The title product was obtained as a crystalline solid, m.pt. 266° C.

Sources & evidence

ORD record
ord-bc2d669ae91a4d3ca99ba757588a1739
Source dataset
uspto-grants-1998_03
Patent number
US05734051

Reaction notes

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