3-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-N-[2-(3,5-dichloro-4-methoxy-phenyloxy)-ethyl]-methylamine

HRID 364112Notes

Reaction equation

HRID 364112 reaction equation
[CH3:1][O:2][C:3]1[C:18]([O:19][CH3:20])=[CH:17][C:6]2[CH2:7][C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14]Cl)[CH2:10][CH2:11][C:5]=2[CH:4]=1.[Cl:21][C:22]1[CH:23]=[C:24]([O:31][CH2:32][CH2:33][NH:34][CH3:35])[CH:25]=[C:26]([Cl:30])[C:27]=1[O:28][CH3:29]>C(N(CC)CC)C>[CH3:1][O:2][C:3]1[C:18]([O:19][CH3:20])=[CH:17][C:6]2[CH2:7][C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14][N:34]([CH3:35])[CH2:33][CH2:32][O:31][C:24]3[CH:25]=[C:26]([Cl:30])[C:27]([O:28][CH3:29])=[C:22]([Cl:21])[CH:23]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 130925103-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-oneHCID 20240116N-[2-(3,5-dichloro-4-methoxy-phenyloxy)-ethyl]-methylamine

Product 1

HCID 20240158N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-N-[2-(3,5-dichloro-4-methoxy-phenyloxy)-ethyl]-methylamine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound is prepared from 3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-1-chloropropane, N-[2-(3,5-dichloro-4-methoxy-phenyloxy)-ethyl]-methylamine and triethylamine analogously to Example 6.

Sources & evidence

ORD record
ord-6ff22932c2694fd3850630b5dd09641f
Source dataset
uspto-grants-1986_08
Patent number
US04604389

Reaction notes

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