3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-1,2-dion-3-yl)-propyl chloride → N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-1,2-dion-3-yl)-propyl]-N-[3-(4-amino-3,5-dibromophenyloxy)-propyl]-methylamine

HRID 364113Notes

Reaction equation

HRID 364113 reaction equation
[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[CH:18][C:6]2[C:7](=[O:17])[C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14]Cl)[CH2:10][CH2:11][C:5]=2[CH:4]=1.[NH2:22][C:23]1[C:28]([Br:29])=[CH:27][C:26]([O:30][CH2:31][CH2:32][CH2:33][NH:34][CH3:35])=[CH:25][C:24]=1[Br:36]>C(N(CC)CC)C>[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[CH:18][C:6]2[C:7](=[O:17])[C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14][N:34]([CH3:35])[CH2:33][CH2:32][CH2:31][O:30][C:26]3[CH:25]=[C:24]([Br:36])[C:23]([NH2:22])=[C:28]([Br:29])[CH:27]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 198474313-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-1,2-dion-3-yl)-propyl chlorideHCID 20240087N-[3-(4-amino-3,5-dibromophenyloxy)-propyl]-methylamine

Product 1

HCID 20240146N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-1,2-dion-3-yl)-propyl]-N-[3-(4-amino-3,5-dibromophenyloxy)-propyl]-methylamine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound is prepared from 3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-1,2-dion-3-yl)-1-chloropropane, N-[3-(4-amino-3,5-dibromophenyloxy)-propyl]-methylamine and triethylamine analogously to Example 6.

Sources & evidence

ORD record
ord-ea3c28581f89490e8301a4ab53bb78d1
Source dataset
uspto-grants-1986_08
Patent number
US04604389

Reaction notes

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