HCID 178464046, compound → HCID 178464040, compound

HRID 364173Notes

Reaction equation

HRID 364173 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:10]2[N:9]([CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[N:8]=[C:7]3[C:20]4[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][C:21]=4[O:22][C:5]=1[C:6]=23)([O-])=O>CN(C=O)C.[OH-].[OH-].[Pd+2]>[NH2:1][C:4]1[CH:12]=[CH:11][C:10]2[N:9]([CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[N:8]=[C:7]3[C:20]4[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][C:21]=4[O:22][C:5]=1[C:6]=23

Participants

4

Reactant 1

HCID 178464046HCID 178464046, compound

Product 1

HCID 178464040HCID 178464040, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 6228DimethylformamideSolvent

Procedure

A solution of 5.0 g of 5-nitro-2-[2-(diethylamino)-ethyl]-2H-[1]benzopyrano[4,3,2-cd]indazol-8-ol in 200 ml of DMF with 0.2 g of 20% palladium hydroxide on carbon was stirred under a hydrogen atmosphere for 24 hours. The mixture was filtered and the filtrate was evaporated in vacuo to leave the product 5-amino-2-[2-(diethylamino)-ethyl]-2H-[1]benzopyrano[4,3,2-cd]indazol-8-ol as an oily solid.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-3ea282be63f840a796f34d271d9e84b3
Source dataset
uspto-grants-1986_08
Patent number
US04604390

Reaction notes

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