Water → HCID 13689067, compound

HRID 364198Notes

Reaction equation

HRID 364198 reaction equation
[CH2:1]([N:3]([CH2:33][CH3:34])[CH2:4][CH2:5][N:6]1[C:14]2[CH:13]=[CH:12][C:11]([NH:15][CH2:16][CH2:17][N:18]3[CH2:22][CH2:21][O:20]C3=O)=[C:10]3[S:24][C:25]4[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:26]=4[C:8]([C:9]=23)=[N:7]1)[CH3:2].[OH-].[K+].O>CO.C1COCC1>[CH2:33]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:14]2[CH:13]=[CH:12][C:11]([NH:15][CH2:16][CH2:17][NH:18][CH2:22][CH2:21][OH:20])=[C:10]3[S:24][C:25]4[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:26]=4[C:8]([C:9]=23)=[N:7]1)[CH3:34]

Participants

6

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 13689066HCID 13689066, compound

Product 1

HCID 13689067HCID 13689067, compoundYield 82.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 8.0 g (0.017 mol) of 3-[2-[[2[2-(diethylamino)ethyl]-9-methoxy-2H[1]benzothiopyrano-[4,3,2-cd]indazol-5-yl]amino]ethyl]-2-oxazolidinone, 70 ml of 2N KOH in MeOH, 35 ml of THF, and 35 ml of H2O was treated and the product isolated as described in Example 56 to furnish 6.4 g of the product, mp 111°-115° C.

Workup

  1. additionwas treated
  2. customthe product isolated

Sources & evidence

ORD record
ord-93de14fab0f34902af378268b9184f9e
Source dataset
uspto-grants-1986_08
Patent number
US04604390

Reaction notes

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