Water → HCID 13377359, compound

HRID 364237Notes

Reaction equation

HRID 364237 reaction equation
[O-:1][CH2:2][CH3:3].[Na+].[Na].Cl[C:7]1[N:12]2[C:13]([CH:16]([CH3:18])[CH3:17])=[N:14][CH:15]=[C:11]2[CH:10]=[C:9]([Cl:19])[N:8]=1.O>C(O)C>[Cl:19][C:9]1[N:8]=[C:7]([O:1][CH2:2][CH3:3])[N:12]2[C:13]([CH:16]([CH3:18])[CH3:17])=[N:14][CH:15]=[C:11]2[CH:10]=1

Participants

6

Reactant 4

HCID 962WaterHCID 2723922Sodium ethoxideHCID 5360545SodiumHCID 13377343HCID 13377343, compound

Product 1

HCID 13377359HCID 13377359, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of sodium ethoxide prepared in ethanol from 0.18 g (7.8 mmole) of sodium metal under nitrogen was added 1.50 g (6.52 mmole) of 5,7-dichloro-3-isopropylimidazo[1,5-c]pyrimidine (from Example 37). After three hours at room temperature the mixture was poured into 50 ml of water and extracted thrice with 30 ml portions of chloroform. The combined extracts were washed thrice with 40 ml portions of water, dried over magnesium sulfate and evaporated to provide crude 7-chloro-5-ethoxy-3-isopropylimidazo[1,5-c]pyrimidine.

Workup

  1. extractionextracted thrice with 30 ml portions of chloroform
  2. washThe combined extracts were washed thrice with 40 ml portions of water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-c3dc47195f16482aba8fa375cc634c88
Source dataset
uspto-grants-1986_08
Patent number
US04604466

Reaction notes

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