反应详情

8-Hydroxy-2-methyl-7-quinolinecarboxylic acid (as reported by Meek, W. H. et al., in J. Chem. Eng. Data 1969, 14(3), 388-91) is reacted with methanolic boron trifluoride solution for several hours. The resulting mixture is added to an aqueous solution of sodium bicarbonate to give finally a basic solution. The solution is extracted with chloroform. The chloroform extract is dried over anhydrous sodium sulfate and concentrated and the residue is crystallized from a suitable solvent such as isooctane to give the title compound.

1. customto give finally a basic solution
2. extractionThe solution is extracted with chloroform
3. extractionThe chloroform extract
4. dry with materialis dried over anhydrous sodium sulfate
5. concentrationconcentrated
6. customthe residue is crystallized from a suitable solvent such as isooctane