反应详情

To a stirred solution of 300 mg of 2'-hydroxy-4,4',6'-trimethoxychalcone in 12 ml of pyridine were added 65 mg of p-(dimethylamino)-pyridine and 165 mg of pivaloyl chloride. After being stirred at room temperature for 4 hours, the reaction mixture was poured into 30 ml of ice-water. The mixture was acidified with hydrochloric acid and then extracted with 50 ml of ethyl acetate. The ethyl acetate extract was successively washed with 0.2N hydrochloric acid, 10% aqueous sodium carbonate and water, dried over sodium sulfate and then evaporated to give 440 mg of 2',4,4'-trimethoxy-6'-(pivaloyloxy)-chalcone;

1. extractionextracted with 50 ml of ethyl acetate
2. extractionThe ethyl acetate extract
3. washwas successively washed with 0.2N hydrochloric acid, 10% aqueous sodium carbonate and water
4. dry with materialdried over sodium sulfate
5. customevaporated