Ammonium Hydroxide → Benzenesulfonamide, 2-(4-isoxazolyl)-

HRID 364846Notes

Reaction equation

HRID 364846 reaction equation
[O:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[S:12](Cl)(=[O:14])=[O:13])[CH:3]=[N:2]1.[OH-].[NH4+:17]>O1CCCC1>[O:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[S:12]([NH2:17])(=[O:14])=[O:13])[CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 134898122-(4-Isoxazolyl)benzenesulfonyl chloride

Product 1

HCID 13489819Benzenesulfonamide, 2-(4-isoxazolyl)-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By the procedure of Example 5, 15 g of 2-(isoxazol-4-yl)benzenesulfonyl chloride prepared in Example 12 was reacted with 30 ml of concentrated ammonium hydroxide in 150 ml of tetrahydrofuran to give, after recrystallization from 2-propanol, 11 g of the title compound; m.p. 165°-167° C.

Workup

  1. customto give
  2. customafter recrystallization from 2-propanol, 11 g of the title compound

Sources & evidence

ORD record
ord-5d6cba0442b74399b6e9c464ec03e485
Source dataset
uspto-grants-1986_08
Patent number
US04606755

Reaction notes

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