p-Toluenesulfonic acid monohydrate → HCID 13765211, compound

HRID 364876Notes

Reaction equation

HRID 364876 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([OH:11])[C:8]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:7][C:6]=1[OH:29])(=O)[CH3:2].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH2:13]([O:12][C:8]1[C:9]([OH:11])=[CH:10][C:5]2[N:4]=[C:1]([CH3:2])[O:29][C:6]=2[CH:7]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 13765210HCID 13765210, compound

Product 1

HCID 13765211HCID 13765211, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture composed of 93.0 g of (1-c), 22.3 g of p-toluenesulfonic acid monohydrate and 1 l of toluene was refluxed with heating for 3 hours to distill away the water formed. After being allowed to cool, the crystals formed were washed with acetone and dried. Yield: 73 g.

Workup

  1. temperaturewas refluxed
  2. temperaturewith heating for 3 hours
  3. distillationto distill away the water
  4. customformed
  5. temperatureto cool
  6. customthe crystals formed
  7. washwere washed with acetone
  8. customdried

Sources & evidence

ORD record
ord-f252c38707b144f3a93af4b46ebbbceb
Source dataset
uspto-grants-1986_08
Patent number
US04606991

Reaction notes

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