Hydrochloric Acid → HCID 13714123, compound

HRID 364887Notes

Reaction equation

HRID 364887 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.[CH:17]1([NH:23][C:24]([N:26]2[CH2:32][CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[O:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.Cl>C(O)CC(C)C>[CH:17]1([NH:23][C:24]([N:26]2[CH2:32][CH2:31][CH2:30][N:29]([C:2]3[N:11]=[C:10]([NH2:12])[C:9]4[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=4)[N:3]=3)[CH2:28][CH2:27]2)=[O:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 16770658HCID 16770658, compound

Product 1

HCID 13714123HCID 13714123, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A solution prepared by dissolving 479 mg. (2 mmole) of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 451 mg. (2 mmole) of N-cyclohexylcarbamoyl-homopiperazine (oily substance, showing IR absorption spectrum at 3340, 2920, 1630 cm-1) in 10 ml of isoamyl alcohol was refluxed for 4 hours, followed by standing overnight. The precipitates were collected by filtration to obtain 310 mg. of the desired hydrochloride.

Workup

  1. customA solution prepared
  2. dissolutionby dissolving 479 mg
  3. filtrationThe precipitates were collected by filtration
  4. customto obtain 310 mg

Sources & evidence

ORD record
ord-94df663e08e84aba94f6cb2b9c0f5f48
Source dataset
uspto-grants-1986_08
Patent number
US04607034

Reaction notes

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