反应详情

温度

90 °C

To 50 ml DMF were added 11-(piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (4.5 g, 0.017 mole), (2-bromoethyl)-benzene (4.3 ml, 0.03 mole), milled K2CO3 (10.0 g, 0.07 mole) and KI (0.01 g). After stirring at 90° C. for four hours the mixture was cooled and filtered, and the filtrate was concentrated in vacuo to an oil. This oil was dissolved in ethyl acetate, washed twice with water and dried (saturated NaCl, anhydrous MgSO4).

1. temperaturewas cooled
2. filtrationfiltered
3. concentrationthe filtrate was concentrated in vacuo to an oil
4. dissolutionThis oil was dissolved in ethyl acetate
5. washwashed twice with water
6. dry with materialdried (saturated NaCl, anhydrous MgSO4)