Dimethylformamide → HCID 20191658, compound

HRID 365140Notes

Reaction equation

HRID 365140 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.[F:21][C:22]([F:32])([F:31])[C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH2:26]Cl.[C:33]([O-:36])([O-:35])=O.[K+].[K+].CN(C=[O:43])C>>[C:9]([OH:8])(=[O:43])[C:33]([OH:36])=[O:35].[F:21][C:22]([F:31])([F:32])[C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH2:26][N:1]1[CH2:2][CH2:3][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 697163-(Trifluoromethyl)benzyl chlorideHCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine

Product 1

HCID 20191658HCID 20191658, compound

Procedure

To 50 ml DMF were added 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (6.0 g, 0.022 mole), 3-trifluoromethylbenzyl chloride (5.0 g, 0.026 mole), milled K2CO3 (10 g, 0.07 mole) and KI (0.01 g).

Sources & evidence

ORD record
ord-adfb9a126aaa429f9947c6e466867613
Source dataset
uspto-grants-1986_08
Patent number
US04608374

Reaction notes

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