Phenyl glycidyl ether → HCID 20237785, compound

HRID 365201Notes

Reaction equation

HRID 365201 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.[NH2:12][C:13]1[N:22]=[C:21]([NH:23][CH2:24][CH2:25][NH2:26])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1>C(O)(C)C>[O:5]([CH2:1][CH:2]([OH:4])[CH2:3][NH:26][CH2:25][CH2:24][NH:23][C:21]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=[C:13]([NH2:12])[N:22]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 31217Phenyl glycidyl etherHCID 20237855HCID 20237855, compound

Product 1

HCID 20237785HCID 20237785, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3.32 g. Phenyl glycidyl ether and 9.0 g. 2-amino-4-(2-aminoethylamino)-quinazoline are stirred for 24 hours at 50° C. in 100 ml. isopropyl alcohol. The reaction mixture is then evaporated and the residue purified chromatographically in the manner described in Example 38. There are obtained 2.0 g. (26% of theory) of the desired product in the form of a colorless oil.

Workup

  1. customThe reaction mixture is then evaporated
  2. customthe residue purified chromatographically in the manner
  3. customThere are obtained 2.0 g

Sources & evidence

ORD record
ord-04f5417ad5cf4f818ffbd271399cb0ee
Source dataset
uspto-grants-1986_08
Patent number
US04608383

Reaction notes

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