Ammonium formate → HCID 23292348, compound

HRID 365501Notes

Reaction equation

HRID 365501 reaction equation
C([O-])=O.[NH4+].[NH2:5][CH2:6][CH:7]([N:20](CC1C=CC=CC=1)[C@@H](C1C=CC=CC=1)C)[CH2:8][CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([F:19])=[CH:14][CH:15]=2)[CH2:10]1>CO.[Pd]>[F:19][C:13]1[CH:12]=[C:11]2[C:16]([CH2:17][CH2:18][CH:9]([CH2:8][CH:7]([NH2:20])[CH2:6][NH2:5])[CH2:10]2)=[CH:15][CH:14]=1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 54248970HCID 54248970, compound

Product 1

HCID 23292348HCID 23292348, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.45 g of ammonium formate is added to a vigorously stirred suspension of 0.35 g (0.84 mmol) of the compound obtained in Step 4 and 0.25 g of Pd/C 10% in 25 ml of CH3OH. After stirring for 1 hour under reflux, the mixture is cooled and filtered; the catalyst is washed with CH3OH and the combined filtrates are concentrated in vacuo to yield the title compound in the form of an oil, which is used without purification in the following reaction.

Workup

  1. temperatureunder reflux
  2. temperaturethe mixture is cooled
  3. filtrationfiltered
  4. washthe catalyst is washed with CH3OH
  5. concentrationthe combined filtrates are concentrated in vacuo

Sources & evidence

ORD record
ord-03888e07dc034d0daa3c4f3e64a01128
Source dataset
uspto-grants-2000_10
Patent number
US06127396

Reaction notes

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