2-Fluorobenzonitrile → ethyl 1-(2-cyanophenyl)-4-piperidinecarboxylate

HRID 365725Notes

Reaction equation

HRID 365725 reaction equation
F[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH:10]1[CH2:20][CH2:19][CH:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:11]1>>[CH2:17]([O:16][C:14]([CH:13]1[CH2:19][CH2:20][N:10]([C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])[CH2:11][CH2:12]1)=[O:15])[CH3:18]

Participants

3

Reactant 2

HCID 678552-FluorobenzonitrileHCID 70770Ethyl 4-piperidinecarboxylate

Product 1

HCID 2764422ethyl 1-(2-cyanophenyl)-4-piperidinecarboxylate

Procedure

According to a similar manner to that in Reference Example 12, the title compound was synthesized from 2-fluorobenzonitrile and ethyl isonipecotate.

Sources & evidence

ORD record
ord-1d02251f5a9e466f957e530bb017dd38
Source dataset
uspto-grants-2000_10
Patent number
US06127541

Reaction notes

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