4-Fluorobenzonitrile → 4-(4-methylpiperazin-1-yl)benzonitrile

HRID 365735Notes

Reaction equation

F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH3:10][N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)[CH2:13][CH2:12]1

Participants

Reactant 2

HCID 145174-Fluorobenzonitrile

HCID 531671-Methylpiperazine

Product 1

HCID 7632054-(4-methylpiperazin-1-yl)benzonitrile

Procedure

According to a similar manner to that in Reference Example 12, the title compound was synthesized from 4-fluorobenzonitrile and 1-methylpiperazine.

Sources & evidence

ORD record: ord-53a89450a2d440ca82db801a15824113
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06127541

Reaction notes

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