Methanol → (3-Bromo-6-hydroxy-2-methylphenyl)(2,3,4-trimethoxy-6-methylphenyl)methanone

HRID 365958Notes

Reaction equation

HRID 365958 reaction equation
C([O:4][C:5]1[CH:25]=[CH:24][C:23]([Br:26])=[C:22]([CH3:27])[C:6]=1[C:7]([C:9]1[C:14]([CH3:15])=[CH:13][C:12]([O:16][CH3:17])=[C:11]([O:18][CH3:19])[C:10]=1[O:20][CH3:21])=[O:8])(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>O>[Br:26][C:23]1[CH:24]=[CH:25][C:5]([OH:4])=[C:6]([C:22]=1[CH3:27])[C:7]([C:9]1[C:14]([CH3:15])=[CH:13][C:12]([O:16][CH3:17])=[C:11]([O:18][CH3:19])[C:10]=1[O:20][CH3:21])=[O:8]

Participants

5

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 109062512-Acetoxy-5-bromo-6,6'-dimethyl-2', 3', 4'-trimethoxy-benzophenone

Product 1

HCID 10938097(3-Bromo-6-hydroxy-2-methylphenyl)(2,3,4-trimethoxy-6-methylphenyl)methanone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 1D (0.7 g, 1.6 mmol), potassium carbonate (0.7 g), methanol (10 ml) and water (5 ml) is stirred at room temperature for 20 hours. The reaction mixture is poured into water and extracted with diisopropylether. The organic phase is separated and concentrated. The pure product is obtained as a yellow solid, 0.48 g (75.9%), mp. 119-120° C.

Workup

  1. extractionextracted with diisopropylether
  2. customThe organic phase is separated
  3. concentrationconcentrated
  4. customThe pure product is obtained as a yellow solid, 0.48 g (75.9%), mp. 119-120° C.

Sources & evidence

ORD record
ord-ee76843728674c7b8b3741362ba4a957
Source dataset
uspto-grants-2000_10
Patent number
US06127570

Reaction notes

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