HRID366043

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

结构：CSC(=NC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1

HCID4664213

未命名化合物

结构：C[C@@H](NC(=O)[C@@H](CCCN)NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1.Cl

HCID131722043

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](NC(=O)[C@@H](CCCNC(=NC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1

HCID178462144

未命名化合物

收率 78.4%

PROCEDURE

实验过程

Prepared according to the method described in Example 4(f) above from (R)-N2 -(diphenylacetyl)-(R)-N-(1-phenylethyl)ornithine amide (0.50 g; 1.0 mmol; from step (c) above), N,N'-bis(Cbz)-S-methylisothiourea (0.40 g; 1.1 mmol) and DiPEA (0.3 mL; 1.6 mmol) yielding 0.58 g (73%) of the sub-title compound as a solid.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad0c475bc1ab4c9785895473f2082abe
来源数据集: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06127414
来源说明: uspto-grants-2000_10

反应 SMILES

Cl.[C:2]1([CH:8]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:9]([NH:11][C@@H:12]([C:17]([NH:19][C@@H:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH3:21])=[O:18])[CH2:13][CH2:14][CH2:15][NH2:16])=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:34]([NH:44][C:45](=[N:48][C:49]([O:51][CH2:52][C:53]1[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=1)=[O:50])SC)([O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:35].CCN(C(C)C)C(C)C>>[C:49]([NH:48][C:45](=[N:44][C:34]([O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:35])[NH:16][CH2:15][CH2:14][CH2:13][C@H:12]([C:17]([NH:19][C@@H:20]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH3:21])=[O:18])[NH:11][C:9](=[O:10])[CH:8]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)([O:51][CH2:52][C:53]1[CH:54]=[CH:55][CH:56]=[CH:57][CH:58]=1)=[O:50]