Hydrochloric Acid → HCID 131722053, compound

HRID 366050Notes

Reaction equation

HRID 366050 reaction equation
C([NH:11][CH2:12][CH2:13][CH2:14][C@H:15]([C:32]([NH:34][C:35]([CH3:43])([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[CH3:36])=[O:33])[NH:16][C:17](=[O:31])[CH:18]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(OCC1C=CC=CC=1)=O.[ClH:44]>CO.[Pd]>[ClH:44].[C:25]1([CH:18]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:17]([NH:16][C@@H:15]([C:32]([NH:34][C:35]([CH3:43])([C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH3:36])=[O:33])[CH2:14][CH2:13][CH2:12][NH2:11])=[O:31])[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131722055HCID 131722055, compound

Product 1

HCID 131722053HCID 131722053, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Prepared according to the method described in Example 1(e) above from (R)-N5 -(Cbz)-N2 -(diphenylacetyl)-N-(1-methyl-1-phenylethyl)ornithine amide (4.21 g; from step (c) above) using 10% Pd/C (200 mg) in 150 mL of MeOH and 1 mL of concentrated HCl, yielding 3.88 g of sub-title compound.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-128889dda2524278b837b7c8215e18bf
Source dataset
uspto-grants-2000_10
Patent number
US06127414

Reaction notes

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