Boron trifluoride etherate → 6,7-Dihydro-5h-benzo[6,7]cyclohepta[1,2-b]quinolin-8-amine

HRID 366379Notes

Reaction equation

HRID 366379 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]#[N:9].[CH2:10]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:13](=O)[CH2:12][CH2:11]1.B(F)(F)F.CCOCC>>[NH2:9][C:8]1[C:3]2[C:2](=[CH:7][CH:6]=[CH:5][CH:4]=2)[N:1]=[C:13]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=3[CH2:21][CH2:10][CH2:11][C:12]=12

Participants

4

Reactant 3

HCID 8000Boron trifluoride etherateHCID 70003BenzosuberoneHCID 729132-Aminobenzonitrile

Product 1

HCID 4026666,7-Dihydro-5h-benzo[6,7]cyclohepta[1,2-b]quinolin-8-amine

Procedure

2-amino-1-cyano-benzene (2.0 g, 16.9 mmol), 1-benzosuberone (6, 7, 8, 9-tetrahydrobenzocyclohepten-5-one) (3.0 g, 18.7 mmol) and boron trifluoride diethyl etherate(1M, 2.6 ml, 18.7 mmol) were treated according to the general procedure described herein to give the title compound.

Sources & evidence

ORD record
ord-d1c7110dad284227a64f47d1282aca0a
Source dataset
uspto-grants-2000_10
Patent number
US06130228

Reaction notes

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