HRID366429

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2735936

Piperazine, 1-(10,11-dihydrodibenzo(a,d)cyclohepten-5-yl)-

C19H22N2

HCID21840791

未命名化合物

HCID23289293

未命名化合物

HCID23289331

未命名化合物

PRODUCTS

生成物

结构：Cc1nc2cccc(OC3CCCC(N4CCN(C5c6ccccc6CCc6ccccc65)CC4)C3O)c2s1

HCID23289234

未命名化合物

HCID23289293

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The title compound was prepared according to Method A from 2-methyl-7-(7-oxa-bicyclo[4.1.0]hept-2-yloxy)-benzothiazole and 1-(10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)piperazine with dioxane/toluene (2:1) as the solvent. mp 207° C. (decomposition); LSIMS m/z 540. The 2-methyl-7-(7-oxa-bicyclo[4.1.0]hept-2-yloxy)-benzothiazole was prepared according to Method IV using THF as the solvent and 4-bromo-2-oxa-bicyclo[4.1.0]heptane as the alkylating agent.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67ee121c137b4d01a6ddf9c39fb83777
来源数据集: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06130217
来源说明: uspto-grants-2000_10

反应 SMILES

[CH3:1][C:2]1[S:3][C:4]2[C:10]([O:11][CH:12]3[CH2:18][CH2:17][CH2:16][CH:15]4[CH:13]3[O:14]4)=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH:19]1[C:29]2[CH2:28][CH2:27][C:26]3[CH:30]=[CH:31][CH:32]=[CH:33][C:25]=3[CH:24]([N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)[C:23]=2[CH:22]=[CH:21][CH:20]=1.O1CCOCC1.C1(C)C=CC=CC=1.BrC1CC2C(C2)OC1>C1COCC1>[CH:30]1[C:26]2[CH2:27][CH2:28][C:29]3[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=3[CH:24]([N:34]3[CH2:35][CH2:36][N:37]([CH:15]4[CH2:16][CH2:17][CH2:18][CH:12]([O:11][C:10]5[C:4]6[S:3][C:2]([CH3:1])=[N:6][C:5]=6[CH:7]=[CH:8][CH:9]=5)[CH:13]4[OH:14])[CH2:38][CH2:39]3)[C:25]=2[CH:33]=[CH:32][CH:31]=1.[CH3:1][C:2]1[S:3][C:4]2[C:10]([O:11][CH:12]3[CH2:18][CH2:17][CH2:16][CH:15]4[CH:13]3[O:14]4)=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1