2-Bromopyridine → HCID 23289237, compound

HRID 366455Notes

Reaction equation

HRID 366455 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1>C(O)(=O)C>[N:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[NH:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 79732-BromopyridineHCID 115683-Aminophenol

Product 1

HCID 23289237HCID 23289237, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3-Aminophenol (3.0 g, 27.5 mM) and 2-bromopyridine (4.34 g, 27.5 mM) were combined in acetic acid (15 mL) and heated for about 18 hours. The mixture was concentrated in vacuo and placed on a column of silica gel (150 g). The product was eluted with 3% methanol/methylene chloride to provide 1.2 g of an off white solid.

Workup

  1. temperatureheated for about 18 hours
  2. concentrationThe mixture was concentrated in vacuo
  3. washThe product was eluted with 3% methanol/methylene chloride
  4. customto provide 1.2 g of an off white solid

Sources & evidence

ORD record
ord-77fc7a6fb10f4c0cba4f33d24b49a9ad
Source dataset
uspto-grants-2000_10
Patent number
US06130217

Reaction notes

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