Hexanal → HCID 54015306, compound

HRID 366851Notes

Reaction equation

HRID 366851 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([O:9][CH3:10])[N:3]=1.[CH:11](=O)[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].C(O)CCCCC>[Pd]>[CH2:11]([NH:1][C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([O:9][CH3:10])[N:3]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

5

Reactant 3

HCID 6184HexanalHCID 81031-HexanolHCID 154662-Amino-4-methoxy-6-methyl-1,3,5-triazine

Product 1

HCID 54015306HCID 54015306, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A 38-mL stainless steel autoclave was charged with 1.40 g (10.0 mmol.) of 2-amino-4-methyl-6-methoxy-1,3,5-triazine, 204 mg of 5-% Pd-carried active carbon, 2.00 g (20.0 mmol.) of 1-hexanal and 15 mL of 1-hexanol. After the inside of the system was fully purged with a nitrogen gas, the reaction was conducted at a reaction temperature of 200° C. for twenty hours and under a hydrogen gas (initial pressure of 50 kg/cm2). After the completion of the reaction, unreacted starting materials were determined. As a result, the conversion ratio of the starting materials was 88.0%. As a result that the reaction product were analyzed, 2-n-hexylamino-4-methyl-6-methoxy-1,3,5-triazine was obtained at a yield of 67.0%.

Workup

  1. customAfter the inside of the system was fully purged with a nitrogen gas
  2. waitthe reaction was conducted at a reaction temperature of 200° C. for twenty hours and under a hydrogen gas
  3. customAfter the completion of the reaction
  4. customAs a result that the reaction product

Sources & evidence

ORD record
ord-f24520b04b7447e0999597c70fbece1d
Source dataset
uspto-grants-2000_10
Patent number
US06130332

Reaction notes

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