Methane → HCID 178430573, compound

HRID 36702Notes

Reaction equation

HRID 36702 reaction equation
[CH2:1]([N:8]=[C:9]([C:11]1[NH:12][CH:13]=[C:14]([CH3:20])[CH2:15][C:16]=1[C:17]([OH:19])=[O:18])[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C>O1CCCC1.[Pd]>[CH2:1]([N:8]=[C:9]([CH:11]1[CH:16]([C:17]([OH:19])=[O:18])[CH2:15][CH:14]([CH3:20])[CH2:13][NH:12]1)[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 297MethaneHCID 178430572HCID 178430572, compound

Product 1

HCID 178430573HCID 178430573, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

17.5 g (70 mmol) of 5-methyl-1,4-dihydropyridine-2,3dicarboxylic acid N-benzylimide are hydrogenated in 150 ml of tetrahydrofuran at 70° C. and under 100 bar over palladium on active charcoal. Then the catalyst is filtered off and the filtrate is concentrated by evaporation. The solid oily residue (13.0 g) is used as a crude product in the next stage.

Workup

  1. filtrationThen the catalyst is filtered off
  2. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-a308aae1db5a42ab888d2ce88b8252cc
Source dataset
uspto-grants-1995_05
Patent number
US05416096

Reaction notes

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