Methanol → HCID 23288077, compound

HRID 367371Notes

Reaction equation

HRID 367371 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.Cl[C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)NC=C2C1CCN(C)CC=1.C[OH:36]>[Pt]>[CH:19]1([O:36][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)[CH2:20][CH2:21][CH2:25][CH2:26][CH2:27]1

Participants

5

Reactant 3

HCID 887MethanolHCID 3061874HCID 3061874, compoundHCID 114139925-Chloro-3-(1-methyl-4-piperidinyl)indole

Product 1

HCID 23288077HCID 23288077, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

5-Chloro-3-(1-methyl-4-piperidinyl)indole: (0.89 g, 88%); from 5-chloro-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)indole (Example 4d, 1.0 g, 4 mmol) and 5% Pt/C (0.78 g, 0.2 mmol) in methanol under H2 ; mp 192-4° C.; HRMS-FAB+ for C14H17N2Cl calculated MH+: 249.11584, found: 249.11529.

Sources & evidence

ORD record
ord-186a5ecc9b764dbf8fe98f433f141ffd
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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