反应详情

温度

80 °C

A mixture of 63.1 g (1.13 mol) of iron powder and 120 ml of an aqueous solution of 5% acetic acid was heated to 80° C., and a mixed solution of 28.0 g (0.113 mol) of N-(4-fluoro-3-nitrophenyl)ethanesulfonamide, 116 ml of acetic acid and 116 ml of ethyl acetate was slowly added dropwise to the resultant mixture. After the reaction was continued for 3 hours, the insolubles were filtered out and washed with ethyl acetate. Thereafter the filtrate was distilled to remove the solvent, and the product was dissolved in ethyl acetate and washed with saturated sodium hydrogencarbonate, water and saturated saline solution. The solution was dried over anhydrous sodium sulfate, and the ethyl acetate was distilled off to obtain the crude product (crystals). The crude product was washed with diisopropyl ether, thereby obtaining 22.0 g of the objective product (yield: 89%) in the form of light yellow crystals.

1. filtrationthe insolubles were filtered out
2. washwashed with ethyl acetate
3. distillationThereafter the filtrate was distilled
4. customto remove the solvent
5. dissolutionthe product was dissolved in ethyl acetate
6. washwashed with saturated sodium hydrogencarbonate, water and saturated saline solution
7. dry with materialThe solution was dried over anhydrous sodium sulfate
8. distillationthe ethyl acetate was distilled off
9. customto obtain the crude product (crystals)
10. washThe crude product was washed with diisopropyl ether