Isopropyl isocyanate → HCID 23288441, compound

HRID 368380Notes

Reaction equation

HRID 368380 reaction equation
[CH:1]([N:4]=[C:5]=[O:6])([CH3:3])[CH3:2].[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][C:9]=1[OH:17]>C1(C)C=CC=CC=1>[CH:1]([NH:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][C:9]=1[OH:17])=[O:6])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 49847212-Amino-5-Nitrophenol

Product 1

HCID 23288441HCID 23288441, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of isopropyl isocyanate (221 mg, 2.6 mmol) in toluene, 2-amino-5-nitrophenol (400 mg, 2.6 mmol) was added. The reaction mixture was stirred at 80° C. for 24 hours, then cooled to room temperature. The product was purified by precipitation from toluene and filtering (570 mg, 92%). m.p: 159.8-161.4° C.; EI-MS m/z 240 (M+H)+.

Workup

  1. temperaturecooled to room temperature
  2. customThe product was purified by precipitation from toluene
  3. filtrationfiltering (570 mg, 92%)

Sources & evidence

ORD record
ord-45aa71747b2e497c81601d849de94ab3
Source dataset
uspto-grants-2000_10
Patent number
US06133319

Reaction notes

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