Cytidine → 2'-O-Propylcytidine

HRID 368731노트

반응식

HRID 368731 반응식
[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[C@H:2]1[OH:3].[H-].[Na+].Br[CH2:21][CH2:22][CH3:23]>CN(C=O)C>[CH2:21]([O:3][C@@H:2]1[C@H:4]([OH:5])[C@@H:6]([CH2:7][OH:8])[O:9][C@H:1]1[N:10]1[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]1=[O:12])[CH2:22][CH3:23]

참가 물질

5

반응물 3

HCID 6175CytidineHCID 78401-BromopropaneHCID 24758Sodium hydride

생성물 1

HCID 228747462'-O-Propylcytidine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Cytidine (16.5 g, 0.068 mol) was treated with sodium hydride (4.5 g) and bromopropane (15 ml) in DMF (150 ml) at room temperature for three days. The resulting reaction mixture was used directly in the next step (see Example 83).

후처리

  1. customThe resulting reaction mixture

출처 및 근거

ORD 기록
ord-10fed2c191df4df088812b3889991aa7
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133438

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