Water → (4-Hydroxyphenyl)acetamide

HRID 368810Notes

Reaction equation

HRID 368810 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][C:7]#[N:8])=[CH:4][CH:3]=1.[OH2:11]>C(O)C>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][C:7]([NH2:8])=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 962WaterHCID 265484-Hydroxybenzyl cyanide

Product 1

HCID 86986(4-Hydroxyphenyl)acetamideYield 98.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(0.0032 g, 0.007 mmol) of the platinum complex, prepared as in Example 1, was stirred with 4-hydroxybenzyl cyanide (1.0 g, 7.5 mmol) and 5 ml (0.28 mol) of water and 5 ml ethanol and the mixture heated under reflux for 18 hours. After cooling the liquids were removed using a rotary evaporator to give 4-hydroxy phenylacetamide (1.116 g) corresponding to 98% yield.

Workup

  1. custom(0.0032 g, 0.007 mmol) of the platinum complex, prepared as in Example 1
  2. temperaturethe mixture heated
  3. temperatureunder reflux for 18 hours
  4. temperatureAfter cooling the liquids
  5. customwere removed
  6. customa rotary evaporator

Sources & evidence

ORD record
ord-4d6952dc87e34863ae75f5dd9576b424
Source dataset
uspto-grants-2000_10
Patent number
US06133478

Reaction notes

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