反应详情

Chlorosulfonyl isocyanate (0.8 ml, 9 mmol) was added to a tetrahydrofuran (50 ml) solution of 3-(3-chlorobenzoyl)-6-ethyl-2-ethylaminopyridine (2.6 g, 9 mmol) under ice-cooling, followed by stirring for 1 hour under ice-cooling. To the reaction solution were added water and saturated sodium bicarbonate aqueous solution in that order, followed by 30 minutes of stirring at room temperature. This was adjusted to pH 10 with 1 N sodium hydroxide aqueous solution and extracted with chloroform. After drying the organic layer over anhydrous magnesium sulfate, magnesium sulfate was removed by filtration and the resulting filtrate was concentrated under a reduced pressure. Thereafter, the resulting residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give 4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one (1.7 g, 60%) in the form of crystals.

1. temperaturecooling
2. temperaturecooling
3. waitfollowed by 30 minutes
4. stirringof stirring at room temperature
5. extractionextracted with chloroform
6. dry with materialAfter drying the organic layer over anhydrous magnesium sulfate, magnesium sulfate
7. customwas removed by filtration
8. concentrationthe resulting filtrate was concentrated under a reduced pressure
9. customThereafter, the resulting residue was purified by silica gel column chromatography (hexane-ethyl acetate)