4-Methylmorpholine → HCID 140376888, compound

HRID 36905Notes

Reaction equation

HRID 36905 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:25]=[CH:24][C:23]([C:26](O)=[O:27])=[CH:22][N:21]=2)=[CH:16][CH:15]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:30]([O:37][C:38]([CH2:40][C:41]1([OH:47])[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)=[O:39])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.CN1CCOCC1>CN(C)C=O>[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:21]=[CH:22][C:23]([C:26]([N:44]3[CH2:45][CH2:46][C:41]([CH2:40][C:38]([O:37][CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[O:39])([OH:47])[CH2:42][CH2:43]3)=[O:27])=[CH:24][N:25]=2)=[CH:16][CH:15]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 194195924-[(Benzyloxycarbonyl)-methyl]-4-hydroxy-piperidine-hydrochlorideHCID 140376887HCID 140376887, compound

Product 1

HCID 140376888HCID 140376888, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared by reacting 2-[4-[N-(benzyloxycarbonyl)-amidino]-phenyl]-5-carboxy-pyrimidine with 1.2 equivalents of N,N-carbonyl-diimidazole in dimethylformamide at 5° C. followed by the addition of 1.2 equivalents of 4-[(benzyloxycarbonyl)-methyl]-4-hydroxy-piperidine-hydrochloride and 1.2 equivalents of N-methylmorpholine at ambient temperature.

Workup

  1. customPrepared
  2. customat 5° C.

Sources & evidence

ORD record
ord-13a85e23a2c849738c637af35a7ea55e
Source dataset
uspto-grants-1995_05
Patent number
US05418233

Reaction notes

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