Trifluoroacetic acid → HCID 23284869, compound

HRID 369073Notes

Reaction equation

HRID 369073 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:20][CH2:19][CH:18]([CH2:21][NH:22][S:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)(=[O:25])=[O:24])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:15]1[CH2:20][CH2:19][CH:18]([CH2:21][NH:22][S:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)(=[O:24])=[O:25])[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22004680HCID 22004680, compound

Product 1

HCID 23284869HCID 23284869, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (10 ml) was added to a solution of N-{[1-(tert-butoxycarbonyl)-4-piperidyl]methyl}pyridine-2-sulphonamide (1.45 g) in dichloromethane (10 ml) and the mixture stirred at ambient temperature for 1.5 hours. The solvent was removed under reduced pressure to yield crude N-(4-piperidyl methyl)pyridine-2-sulphonamide trifluoroacetate.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-ad49eaa491e44d54b02c5b0ebbd921af
Source dataset
uspto-grants-2000_10
Patent number
US06136825

Reaction notes

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