Methylamine → HCID 23284794, compound

HRID 369217Notes

Reaction equation

HRID 369217 reaction equation
[CH3:1][NH2:2].[NH2:3][C:4]1[C:5]([F:28])=[CH:6][C:7]([F:27])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17](F)[C:18]=3[Br:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[CH:9]=1>N1C=CC=CC=1>[NH2:3][C:4]1[C:5]([F:28])=[CH:6][C:7]([F:27])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17]([NH:2][CH3:1])[C:18]=3[Br:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[CH:9]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 10895291HCID 10895291, compound

Product 1

HCID 23284794HCID 23284794, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 40% aqueous solution (150 mg) of methylamine and 1-(5-amino-2,4-difluorophenyl)-8-bromo-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (150 mg) were added to pyridine (3 ml), and the mixture was stirred at room temperature for 2 hours. After the solvent was distilled off under reduced pressure, a mixed liquid of ethanol and diethyl ether was added to the residue, and solids were collected by filtration to obtain the title compound (40 mg) as a light brown powder.

Workup

  1. distillationAfter the solvent was distilled off under reduced pressure
  2. additiona mixed liquid of ethanol and diethyl ether was added to the residue, and solids
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-f11dd7715c434dda9908e7b26f4f0e7e
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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